1 Use of iohexol clearance in dogs as a diagnostic test – does it help in early diagnosis of kidney disease? Dr. L. PELLIGAND, DMV, Cert. VA, Dipl. ECVAA Dipl.

An iohexol clearance test is commercially available for dogs and cats at the Diagnostic Center for Population and Animal Health—Toxicology Section of Michigan State University. To perform this test, the patients should be well hydrated and fasted 12 hours before the study.

This enables GFR to be accurately determined with only 3 samples after application of a correction formula. kg). P-Cre in larger dogs correlated better with PCio than in smaller dogs, suggesting that P-Cre in larger dogs was a more sensitive marker of reduced GFR. KEY WORDS: body weight, plasma creatinine, plasma iohexol clearance, plasma urea nitrogen. J. Vet. Med. Sci. 72(9): 1129–1136, 2010 Chronic kidney disease (CKD) is one of the most com- iohexol clearance In this test, 300 mg/kg of iohexol, a commonly used radiographic contrast agent, is administered intravenously, and blood samples are typically drawn two, three, and four hours later.1,2 The timing of sample collection is flexible, but the exact time the samples were drawn needs to be accurately recorded so the precise time elapsed since injection can be calculated. Iohexol plasma clearance as a measure of glomerular filtration was determined in 31 dogs and 19 cats after an intravenous (i.v.) bolus injection. All animals were healthy and privately owned. Serial blood samples were taken before and up to 4 h after tracer injection.

Iohexol clearance test dog msu

Iohexol plasma clearance as a measure of glomerular filtration was determined in 31 dogs and 19 cats after an intravenous (i.v.) bolus injection. All animals were healthy and privately owned. Serial blood samples were taken before and up to 4 h after tracer injection. Iohexol plasma concentration was determined using X-ray fluorescence.

kg). P-Cre in larger dogs correlated better with PCio than in smaller dogs, suggesting that P-Cre in larger dogs was a more sensitive marker of reduced GFR. KEY WORDS: body weight, plasma creatinine, plasma iohexol clearance, plasma urea nitrogen. J. Vet. Med. Sci. 72(9): 1129–1136, 2010 Chronic kidney disease (CKD) is one of the most com-

Test bolus dogs received a manually injected test bolus of iohexol 300 IOHEXOL CLEARANCE. In this test, 300 mg/kg of iohexol, a commonly used radiographic contrast agent, is administered intravenously, and blood samples are typically drawn two, three, and four hours later.1,2 The timing of sample collection is flexible, but the exact time the samples were drawn needs to be accurately recorded so the precise time In a recent publication, Delanaye et al. (21,22) reviewed the use of iohexol plasma clearance for GFR measurement in both clinical and research settings in depth. Comparisons between iohexol and inulin clearance, as well as with other reference markers, such as iothalamate and radiolabeled tracers, have been discussed exhaustively.

To perform test: • Accurately administer a single dose of Iohexol at 300mg iodine/kg (I.V.) through an intravenous catheter and then flush well with 0.9% saline. Record the time to the nearest minute. • Draw a minimum of 1 ml blood for cats/ 2ml blood for dogs at 2 hr, 3 hr and 4 hr after administration (record exact time).

2 Several methods for measuring GFR have now been validated in dogs and cats, including plasma clearance techniques using non-radioactive markers such as creatinine and iohexol… Recently, tests using iohexol, a radiographic contrast agent, have been developed to estimate the GFR in human beings, dogs and cats with results that have been validated by traditional standards. Most testing protocols require a single bolus injection of iohexol, followed by 2 … test is suggested approximately 2 to 3 weeks after an iohexol clearance in that age group. Clinical Reference 1. Brown SC, O'Reilly PH: Iohexol clearance for the determination of glomerular filtration rate in clinical practice: evidence for a new gold standard. J Urol 1991;146:675-679 2. clearance compared with creatinine clearance is 1.09 (95% CI, 1.03-1.15).

NCI Thesaurus (NCIt) Iohexol is a benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.
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What do I need to tell my doctor BEFORE I take Iohexol? All products: If you have an allergy to iohexol or any other part of iohexol. If you are allergic to iohexol; any part of iohexol; or any other drugs, foods, or substances. BSAVA Manual of Canine and Feline Clinical Pathology, 3rd edition.
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Each dog received each CT technique 6–8 weeks apart starting with bolus tracking with each dog receiving 2 ml/kg iohexol (300 mgI/ml – total dose 600 mg/kg) (Omnipaque, Adcock Ingram Healthcare, Bryanston South Africa) administered with a pressure injector at 3 ml/sec. Test bolus dogs received a manually injected test bolus of iohexol 300 mgI/ml (15% or 0.3 ml/kg of the total dose of 2 ml/kg) followed by an additional dose of 2 ml/kg administered with a pressure injector at 3 ml/sec.

Technique (intrinsic) limitations. Multisample plasma clearance techniques are labor-intensive and expensive. It does not require any specialized equipment or urine collection and can be completed in four hours.36,37 (Iohexol measurement for the iohexol clearance test is available at the Diagnostic Center for Population and Animal Health, Michigan State University, 4125 Beaumont Road, Lansing, MI 48910-8104; phone: (517) 353-1683; FAX: (517) 353-5096; www.animalhealth.msu.edu.) Each dog received each CT technique 6–8 weeks apart starting with bolus tracking with each dog receiving 2 ml/kg iohexol (300 mgI/ml – total dose 600 mg/kg) (Omnipaque, Adcock Ingram Healthcare, Bryanston South Africa) administered with a pressure injector at 3 ml/sec. Test bolus dogs received a manually injected test bolus of iohexol 300 mgI/ml (15% or 0.3 ml/kg of the total dose of 2 ml/kg) followed by an additional dose of 2 ml/kg administered with a pressure injector at 3 ml/sec. Serum iohexol concentration is measured using deltaDOT High Performance Capillary Electrophoresis technology.